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A Motivating Loss

Greetings on a rainy Saturday. Harriet and I attended the memorial service for Denise Robbins this morning. As I noted last week, Denise succumbed to breast cancer about 10 days ago. David, his family and friends were joined at the service by many members of his Georgetown family. The service was filled with the ache of loss, the warmth of remembrance and the closeness of a caring community.

There is something special about Georgetown Lombardi. Several attendees noted that this level of community, compassion and care is regrettably unusual in the academic world. Just think of it: David and Denise moved to D.C. in the middle of the pandemic, when most people worked from home. Even now, the campus has not fully recovered the buzz that comes from human contact and not through screens. Despite these challenges, David and Denise became treasured members of our Georgetown Lombardi family and forged bonds that helped to sustain them during unimaginable difficulties. There is nothing like actual contact and real friendships to add important, life-affirming depth to the work that we do.

Make no mistake, that work is important. I frequently crow about the progress we have made in the war on cancer. Denise’s tragic loss is a harsh reminder that we don’t have the answers for all of our patients, despite that progress. So, today I am wrestling with a complex brew of sadness, the warmth that comes from a sense of belonging, and determination to use the time left to me to make a difference by contributing to our shared mission.

May Denise rest in peace, and may David be comforted by our caring community.

Stay safe and be well.

Lou


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.

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Match Day

Greetings on a brilliant late winter Saturday afternoon. Our lab submitted a couple of papers this past week, and our fingers are now crossed. Wednesday was notable for the first post-COVID “Lunch with Lou,” where I met with our early career faculty council under the auspices of our cancer center’s DEI program. We went through their thoughtful agenda of questions, and I came away energized and hopeful for the future of cancer research.

Right after that, the Cancer Host Interactions (CHI) program meeting featured a presentation by Chul Kim regarding the use of immune checkpoint inhibitors in HIV-positive patients with non-small cell lung cancer. Interestingly, Chul has found that HIV positive patients can respond well to these inhibitors, with acceptable toxicities as well. Chul epitomizes a translationally oriented clinical investigator, with the depth to meaningfully team up with Georgetown Lombardi scientists. He has great collaborations to incorporate imaging mass cytometry with Marta Catalfamo.

I then hurried over to the Fischer Colloquium in the McDonough School of Business for the 2024 Innovation Awards Ceremony. Recent patentees received plaques or glass statues (including our own Jill Smith), and there were several wonderful speakers, including the Commissioner of the U.S. Patent Office. It was a lovely ceremony, and it highlighted the significant innovation coming out the institution as a whole, and from the cancer center in particular.

Finally, the 2024 resident match took place on Friday. All four of our graduating MD/PhD students matched at wonderful institutions: Jerry Xiao at UCSF (Internal Medicine), Irfan Khan at Cedars Sinai (Radiation Oncology), Joey Posner at Johns Hopkins (Pediatric Neurology) and Joshua McCall at Vanderbilt (Neurology). You may know one or more of these wonderful students, and I am certain you share in my congratulations to them and to Todd Waldman, who has organized a very successful program. Having had the opportunity to mentor two MD/PhD student in my lab who went on to top internal medicine residency programs, it is clear that Georgetown is able to attract and support budding superstars. Congratulations to this year’s graduating class!

Stay safe and be well.

Lou


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.

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Building a Stronger Foundation

After 10 days of work-related travel connected to a bit of free time to visit family in California and Philadelphia, I returned to an exceptionally busy week of work. However, there was a clear highlight for me. On Monday and Tuesday the Executive Committee of the cancer center convened at 2115 Wisconsin Avenue with additional Lombardi members to build a foundation for our next five years.

We reviewed the CCSG Summary Statement, incorporated its comments and suggested action items into our existing 2021-2026 Strategic Plan, and then focused on what I proposed were the four major action items we must address to support our future success as an NCI-designated comprehensive cancer center:

  • Obtain three or more multi-project, multi-PI grants, such as P01, U54 or SPORE grants, that span the Georgetown Lombardi Consortium. To achieve our goals of three such grants, we recognized that we will need to advance about 15 multi-PI projects to be able to get three or more of them funded within five years. Of course, even more than three such projects would be great, and they would increase our impact and funding base.
  • Increase transdisciplinary collaboration and coordination (multiple clinical disciplines/departments across the consortium, evidenced by joint publications and grants).
  • Increase the accrual of patients to high-impact clinical trials linked to Georgetown Lombardi science. We have made significant progress and can support 600+ therapeutic accruals annually across the consortium, and aim for 800+ accruals within five years. I am confident we can achieve these goals. Linking accruals with Georgetown Lombardi science will be critically important, but that is the fun part!
  • Continue recruitments in accord with the CCSG Strategic Plan to increase our research depth (currently about $22M annual direct costs of cancer-focused research funding, up from about $13M in 2018). We aim to approach the median cancer-focused funding of NCI-designated comprehensive cancer centers; while it will take time, maintaining our upward trajectory is an urgent priority for continued future NCI designations. We are moving forward with recruitment plans over the next few months.

Buoyed by significant investments by Georgetown University, Hackensack Meridian Health and MedStar Health, we have the bandwidth to execute these priorities. We were excited to consider strategies for new developmental projects and settled on a strategy to iteratively identify project teams who will receive Georgetown Lombardi support to work towards multi-PI projects. We aim to do this yearly, with options for one-year renewals of support (based on progress reports). We anticipate that the selected teams will address important problems, and that teams will be composed of members whose funding profiles and histories increase the likelihood of success.

Our first three priorities are a developing a U54 focused on Minority Health and Health Disparities, led by Lucile Adams Campbell; a team focused on colon cancer biology and therapy, led by David Robbins and Binfeng Lu; and a team addressing the epigenetics of tumors and the host immune response, to be led by Yi Zhang and Nagi Ayad, along with Chunling Yi. Each of these teams has been charged with creating a brief proposal that will be reviewed over the next month or so, with funding to commence by May. The next group of project teams will be solicited after July 1.

We are really excited about this initiative and expect that these efforts will help us achieve our key goals and spin off additional activities that engage all of us in this progress.

Stay safe and be well.

Lou


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.

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Work-Life Balancing Act

Greetings on a cold Presidents Day Weekend. We took a break and went to the beach, avoiding the non-catastrophic non-blizzard that was predicted for DC. It’s beautiful and quiet here, but when we went to a popular local restaurant on Friday evening it was pleasantly filled. It has been a most relaxing weekend, and I for one needed it after a very busy past two weeks.

We are in budget and faculty evaluation season. I saw a few patients. I also interviewed two candidates as potential successors to Sandy Jablonski in my lab. We put in the finishing touches and submitted Zoe Malchiodi’s wonderful first-author paper on natural killer cells in pancreatic ductal adenocarcinoma. I cannot believe how much work is required to submit papers to high-impact journals. To think that I imagined that the pace of my work life would be less frenetic after the CCSG competitive renewal site visit! I could not have been more wrong.

I participated in a very interesting daylong Georgetown University Executive Committee retreat that focused on leadership in these challenging times. Plus, on Friday I co-chaired a virtual NCI study section to review NCI R35 outstanding investigator awards. I personally reviewed nine proposals, and was simply awed by the extraordinary talent and high accomplishments of the people who applied. It makes Jeanne Mandelblatt’s successful R35 award last month that much more impressive to me. There is no higher bar of peer recognition in our field, in my opinion.

The coming week will be busy as well, but then I have a break of sorts. Harriet and I will be flying to California over the weekend. We’ll spend a couple of days visiting one of her cousins in Palm Springs, and then will drive down to La Jolla, where I will chair the EAB for the Sanford Burnham Prebys NCI-designated cancer center. We then fly directly from San Diego to Philadelphia for Fox Chase Cancer Center’s EAB meeting — a mock Site Visit rehearsal. We’ll then spend a night or two with our son Ken and his family before heading home. So, it will be a combination of hard work and fun.

Because I will be traveling, I will hold off on blogs for the next week or two. In the meantime, stay safe and be well.

Lou

 

 


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.

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Super Bowl Sunday

Greetings on Super Bowl Sunday! I had a very busy week that included a trip to California to chair a cancer center EAB. It’s always a great education for me, even as we provide service to our colleagues. I landed on Friday evening, and on Saturday we trained up to Philadelphia to help our son Ken and his youngest child, Isabelle, celebrate their birthdays.

There will be no let up this week, with tons of budget-related meetings and a GU Executive Committee retreat on Thursday, followed by an NCI R35 virtual study section meeting on Friday.

At least for tonight I will kick back a bit and will enjoy the Super Bowl.

Stay safe and be well.

Lou

 

 


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.

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Ringing and Answering the Bell

It has been a crazy busy week. I put the finishing touches on a new R01 proposal that focuses on NK cell migration in pancreatic ductal adenocarcinoma. I gave two lectures for grad students, and had wall-to-wall meetings every day of the week. After Alex Lekan, an MD/PhD student in my lab, gave his excellent Data Meeting presentation on Thursday morning, I had a busy clinic that afternoon and then gave a joint presentation with Ben Weinberg about our pancreatic cancer research to the Immunotherapy and Heme Malignancies Working Group at the end of that day.

I then went up to Hackensack on Friday with Sharon Levy for meetings to discuss our consortium plans moving forward. My train left DC at 7 a.m., and I returned at 6 p.m. and went straight from Union Station to the Kennedy Center, where Harriet, I and some friends had dinner before we saw the musical “Tick, Tick, Boom.” It was very good, but I must say that I preferred Sondheim’s “Merrily We Roll Along,” which we saw in New York City the previous weekend. 

On Saturday, Harriet and I went to the Georgetown basketball game, where I and a group of BellRinger stalwarts accepted an oversized check at a half court ceremony at halftime for the proceeds from our ride in October. The Capital One Center was buzzing with a pretty big crowd (they came for the Hoyas, not for our BellRinger group!). Even though Marquette thumped the Hoyas, it is clear to me that Coach Cooley has his team playing hard and has the program on the right track.

By the way, almost 230 people have signed up already to ride in BellRinger 2024, less than two weeks after registration for the event opened. What a great way to answer the bell! We are way ahead of last year’s pace. Let’s keep it going!

It was wonderful to take a break on Sunday to have people from the lab over for a brunch to celebrate Sandy Jablonski’s retirement. I wrote about her last month, but as I finished off the grant this week I thought about all we’ve accomplished, and so much of it happened because of her. I’m looking for her successor, though she will never be replaced. Speaking of BellRinger, we have a few of the small bells that were handed out at the finish lines of the 2023 ride. Every time someone has a good result to share at our lab meeting, they get to “ring the bell.” It’s a wonderful new lab tradition.

I have to head out to the West Coast later this week to chair the University of California, Irvine Chao Family Comprehensive Cancer Center EAB meeting. That will be a lot of work too, but I look forward to catching up with some recreational reading on the plane. I finished off Michener’s “Chesapeake” a couple of weeks ago and am now plowing through Walter Isaacson’s biography of Henry Kissinger. Fascinating stuff.

Finally, congratulations to Jeanne Mandelblatt for being one of the small cadre of cancer research superstars to receive an R35 Outstanding Investigator Award from the NCI. The awards were just announced. It is a testament to her exemplary work and to the confidence of rigorous peer reviewers that her remarkable, highly impactful productivity will continue.

Sometimes, crazy busy can be good. Have a great weekend, and remember to stay safe and be well.

Lou

 

 


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.

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Theater Magic

Greetings on a rainy weekend. Harriet and I made a weekend excursion up to New York and had a marvelous time. We took train up on Friday and had a great meal at a Greek restaurant, Avra, in Rockefeller Center. Our hotel was located in Midtown, so we were able to walk there, and everywhere else we wanted to go, pretty easily.

Longtime readers of this blog may remember that we spent a lot of time in Manhattan when our youngest grandson was born in 2021 and needed repair of a coarctation of the aorta when he was a week old (btw, he is doing incredibly well, and has no limitations of any kind). The contrast in New York between then and now is quite striking. Midtown and the Theater District are bustling; we walked wherever we wanted, and it both felt and was quite safe.

On Saturday we walked to the Museum of Modern Art, where we got wonderful inspiration for some paintings Harriet is working on to complement poems I have written about my mother’s experiences as a “hidden child” in Belgium during the Holocaust. My brother wrote a book chronicling her experiences, built around letters she sent to her parents while hiding as a novice in a convent.

Interestingly, our oldest grandchild, who is in the seventh grade, is doing a class project on the Holocaust, as his class recently visited the Holocaust Museum here in DC. The book he ordered for his project did not arrive in time, so he read my brother’s book and will use it as the basis for his project. The stories and memories are hard, but the lessons are so important, particularly at this moment, when all types of intolerance are on the rise. I hope that all of our grandchildren eventually read the book and carry that piece of their legacy with them, transmitting those lessons to future generations.

So, after the museum, we went to the nearby Lego Store, and bought some things for our youngest grandsons. We walked about and had a pre-theater dinner before seeing Sondheim’s “Merrily We Roll Along” at the Hudson Theater. The musical has a star-studded cast that includes Daniel Radcliffe of Harry Potter fame. He is quite the accomplished stage actor!

The show was simply exceptional. It first opened in 1981, and was a miserable flop, even though the score contains some of Sondheim’s iconic songs. Over the years, various productions have improved the book and unusual organization of the story (it starts at the end and works its way back to the beginning, where one sees the origins of the various conflicts of the story). My brother, a composer who knew Sondheim, thinks it may be his best work in terms of musical theater craft.

We turned off our phones during the show, but when I turned mine back on at intermission, waiting for me was a text from my brother telling me that his daughter, whose stage name is Marla Mindelle, just won a 2024 Obie Award (the off-Broadway equivalent of a Tony Award) for her lead performance in the musical parody “Titanique,” which she also co-wrote.

It is a towering accomplishment for any theater performer, and we simply could not be more thrilled and proud of her. I remember her as a 3-year old at an ice cream parlor in Newtown, Penn., who out of nowhere would jump on top of the table where she was supposed to be sitting to “entertain” the customers with her version of the song ‘Tomorrow,” the iconic anthem of the hit musical “Annie.” Again and again and again, and everywhere we ate… She was born to sing and perform, and her dreams have come true. She is extraordinarily talented, of course, but her talent is only exceeded by her hard work.

If my mother had not survived the Holocaust, there would have been no Marla. Every life is precious.

Stay safe and be well.

Lou

 


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.

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BellRinger!

I hope you had a good (though no doubt chilly) weekend!

Last week began with the observance of the Dr. Martin Luther King, Jr. holiday, then was bookended by snowstorms. I had unexpected opportunities to work on a new R01 submission that is shaping up nicely. Although Grand Rounds by Dr. Barbara Burtness had to be done virtually due to Friday’s snowstorm, I was delighted to meet with her and then attend her presentation. I had the privilege of recruiting Barbara from Yale to Fox Chase when I worked there; she actually covered my patients for me a few times. She left Fox Chase a few years after I did and returned to Yale. Her career, which was already ascendant, has really gone into hyperdrive, and her presentation was spectacular. I very much enjoyed catching up with her. She epitomizes the value of the translational physician investigator.

In other news, it’s hard to believe that it’s time to renew our focus on BellRinger! Last October’s ride was an unqualified success and serves as a motivator for BellRinger 2024, which will be held this October.

BellRinger is not a race, it is a ride. It is a ride, and yet it’s more than that — it is the realization of our passionate commitment to end cancer as we know it. Georgetown University’s ambitious Capital Campaign is known as “Called to Be”; we are “Called to Cure.” In 2024, 2 million Americans will be diagnosed with cancer, and just over 600,000 will lose their battle with the disease. This 70% cure rate represents a remarkable improvement in survival since 1971, when President Nixon declared a war on cancer, and much of that improvement has occurred in the last 25 years.

With continued research to find new treatments, earlier detection and better cancer prevention strategies, we are poised to accelerate this progress. But it cannot happen without money. And this is where BellRinger comes in. Funds raised by the ride support cancer research at Georgetown Lombardi, filling in the critical gaps that are not covered by grants, foundations and other forms of philanthropy. BellRinger funds fuel our discoveries.

BellRinger is more than a ride, it is a mission — a mission to support clinical trials, new recruits and early stage investigators. Importantly, it is an absolute blast, a great ride with top-notch organization, great support and wonderful food. It engages our community in new ways as we take action (in the form of both pedaling and raising money!), and together we make a difference. Each one of us can help — as a rider, fundraiser or volunteer. Last year, we had almost a thousand riders, and this year we want to blow past that number and have at least 1,200 riders.

Kickoff activities start this week. Please get ready to sign up, form or join a team and prepare for a great ride in October!

Stay safe and be well.

Lou

 


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.

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Lasting Impact

Greetings after the long weekend, which included observance of the majestic life, work and lasting impact of Rev. Martin Luther King, Jr. In musing about King’s impact, I could not help but share with you a remarkable story from this past week.

On Friday, we rededicated the Lombardi Atrium as the Founder’s Atrium in honor of Georgetown Lombardi’s founding director, Dr. John Potter. It was a marvelous tribute to Dr. Potter, whom I have written about extensively, most recently after he passed away at the age of 95 almost two years ago. His painting, which hangs in the Lombardi Atrium, was moved closer to the main entrance, in a place of honor. The Atrium was already a beautiful space, enhanced by the works of Sam Gilliam and William Wegman, thanks to the efforts of Julia Langley and our Arts & Humanities Program. Now it is special because it celebrates our history.

John’s children and grandchildren attended the ceremony, where Dr. Lisa Boyle and I reflected on the lasting impact of a single man who had a great idea that has brought comfort and cure to countless thousands of patients since Georgetown Lombardi was founded in 1970. After the ceremony, we sat down to a luncheon in the Martin Marietta Conference Room, and John’s children offered reflections about their father.

After his sisters, Tanya Potter Adler and Muffie Potter Aston, spoke, John Potter stood up and told us a story, one that began both on that day and also many years ago. None of this was planned, making it all the more remarkable.

After the ceremony, a nice gentleman who works in the lobby area had motioned over to John to speak with him. This is what he told him.

Years ago, his mother had worked at the CIA. In the matter of a few days, she learned that she was pregnant and that she had a breast mass. The doctors she consulted recommended that she terminate her pregnancy so she could get her cancer treatments. She decided to speak with a doctor who was also working at the CIA — Dr. Potter.

He reassured her that she could safely continue her pregnancy while receiving her treatments. She did, and our colleague was born and lived to work at our cancer center. His mother never suffered a relapse of her cancer and lived for another 35 years. The work John did — and that we do — lives on. When that man walked into Martin Marietta to tell us how grateful he was to have life because of John, he was the living personification of high impact! What a great moment.

After the applause died down, I then introduced the last two Potter Award recipients, Drs. Chiranjeev Dash and Chul Kim. While the day’s festivities honored our past and the impact of Dr. Potter’s vision, Dash and Chul embody Georgetown Lombardi’s present accomplishments and bright future.

It all started with a great idea and the determination of a Georgetown bulldog. And it continues.

Have a great week, and remember that what we do has high impact, and we all are part of it.

Stay safe and be well.

Lou

 


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.

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Happy New Year!

Happy New Year! I hope your 2024 is off to a good start. We had a wonderful winter break, filled with family and friends, and even a five-day visit to the beach. I know it is not for everyone, but I love being at our beach house in the winter when the area is quiet but the restaurants are open!

I am fully back in the swing of things at work, energized and looking forward to executing the plans we have for the cancer center. Also, I am finishing off another R01 proposal that focuses on improving NK cell infiltration of pancreatic cancer, as we tee up additional future grants.

It’s amazing to me how much time and head space have cleared up now that the CCSG competitive renewal has receded a bit into my rearview mirror. Beyond the energy I am able to bring to the cancer center and to my lab, I find that I now have both the time and inclination to spend more time reading for pleasure. I feel like I have awakened a nearly forgotten part of my true self. In the past month or so I read “21 Lessons for the 21st Century” by Yuval Noah Harari, the author of “Sapiens.” His perspective on the challenges and opportunities humankind faces as a result of technology advances is remarkable and enlightening. I also enjoyed “Gangsters of Capitalism,” which chronicled the life of Smedley Butler, a Marine who was a key participant in many American misadventures in the Caribbean, Central and South America, and the Philippines, all of which led him to denounce imperialism. It makes for a fascinating read.

Perhaps as a counterpoint, I then read the autobiography of Antonio Mendez, “Master of Disguise,” which chronicles his life and career with the CIA. Mendez was the architect of the Argo operation that freed six American hostages from the Canadian Embassy in Iran. His book reminded me of the courage and patriotism that inspires risky public service. Then, I finally got around to “Chesapeake” by James Michener; it is a huge, sprawling historical novel that I have always meant to read. I have long enjoyed Michener’s books, and it is an especially wonderful book to read while living in DC and having a vacation home at the Delaware beaches. I have gotten through the first 400 pages — only 600 more to go! What I find astonishing is how this book, written nearly 50 years ago, is so evocative of themes that persist to this day, such as the legacy of slavery, women’s rights and class distinctions. Plus, I am learning a lot about the history of the region! It’s a marvelous read. The coming week promises to be very busy, but now that I am back in the habit of reading, I plan to set a little time aside every day to read and see the world though different eyes.

Meanwhile, the new year has brought with it a highly infectious COVID strain. Please remember to take reasonable precautions, and as always, stay safe and be well.

Lou

 


The views, thoughts, and opinions expressed in the text belong solely to the author, and not necessarily to the author’s employer, organization, committee or other group or individual.