Categories
Clinic Events

Obligation and Opportunity

I’m glad that so many Lombardi faculty and staff were able to attend last week’s Town Hall meeting on Health Disparities in the Research Building Auditorium. The panel engaged in a lively discussion regarding the important issue of health disparities with a focus on the District of Columbia. Lucile Adams-Campbell really represented Lombardi in a thoughtful and persuasive manner. Another highlight of the session was the powerful presence of Tovoia Miner, who relayed her experience with breast cancer and the role the Capital Breast Care Center played in assuring timely diagnosis and therapy. I am proud of what Lombardi is doing in the area of Health Disparities and look forward to even more impact from these efforts with Lucile’s leadership. I’m also appreciative of the efforts of the Friends of Cancer Research in conceiving of and organizing this important event.

For those of you whose work infrequently crosses into the Cancer Center’s clinical activities, one area that I’ve been interested in strengthening is multidisciplinary patient care and research. This requires an expansion of Lombardi’s focus beyond medical hematology and oncology to more fully engage our colleagues in radiation oncology, surgical oncology, and other sub-specialties. Several weeks ago I met with a number of the clinical department leaders to describe what Lombardi is doing and to solicit ideas about how we can work together more effectively. It was a pleasure to meet with Bruce Luxon, the new Chair of Medicine, and to continue to work with Greg Gagnon in Radiation Medicine. I was pleased to see Lynt Johnson, who is Interim Chair of Surgery, and discuss ways to incorporate surgical oncology into Lombardi’s research portfolio. I was doubly pleased when Lynt revealed that he not only loves golf, but is as bad at it as I am. I look forward to sharing a few shanks with him in the future.

Finally, on Thursday and Friday I’ll be representing Lombardi at the NCI Translational Science Meeting, called TSM 2. Fortunately, the meeting doesn’t require substantial travel as it will be held in Tyson’s corner. Before I head out on Thursday, I will be giving the Department of Medicine Grand Rounds lecture in the Gorman Auditorium. I hope to see some of you there.

Categories
Events Outreach

Still Recovering… (or, John Marshall is the Fifth Beatle)

Now that the NCI Site Visit is over, things are beginning to settle down a bit, I had the great fortune to attend a spectacular event this past Tuesday evening in the Riggs Library to honor Jeanne Ruesch and her family for donating $6.75 Million to establish the Otto Ruesch Center for the Cure of Gastrointestinal Cancers. The event was attended by many of Georgetown’s leaders, along with some friends of the Ruesch family. One of them, who used to work in E501 for Phyllis, was successfully treated for a seminoma by Nancy Dawson shortly after she arrived here; I am sure Nancy’s ears were burning as a result of the lavish praise that was tossed around about her skills as a physician and as a warm and caring person.

During the meal, I had the privilege of making a few remarks and introducing the star of the evening, John Marshall, who will direct the Ruesch Center. I do not exaggerate when I tell you I truly was the warm-up act for a superstar. John’s powerful and totally captivating presentation mesmerized the gathering; he embodied humanism, clinical virtuosity, soaring ambition, and a profound sense of the value of every single human life. In short, he exemplified cura personalis, and embodied everything that is good about Georgetown, and about Lombardi. I was humbled and honored to share the dais with him. To give you an idea of how he touched all of us, the Georgetown University Executive Committee met on Wednesday and Thursday, and at least four different speakers referred directly to John’s presentation as a prime example of how Georgetown University’s values can translate into action. Of course, both John and I expressed our profound gratitude to the Ruesch family for making John’s vision come to life. The establishment of the Ruesch Center will long be remembered as the critical event in the evolution of our efforts to make a difference in these challenging diseases.

On another note, please check out Lombardi’s presence as a sponsor of WashFM’s breast cancer awareness month activities. I am very pleased to see (hear?) us reaching out into the community in this way.

Categories
CCSG Events Research

Army generals and handprints

After a week of vacation and our Town Hall Meeting, I’m back to the blog.

As you know, we launched the new Lombardi website on July 1st. You can read about the changes we’ve made on the new Lombardi Magazine website. There are a number of improvements to the new site, but I want you to know that there is still more to come. The next projects under development by Mark Goetz and Allison Whitney are the capability to provide individual faculty with laboratory pages that they can update and an internal website to help Lombardi faculty and staff access the various resources at their disposal. We’d love to hear your comments on the site. Feel free to leave a note here, or email Mark or Allison.

Over the past two weeks we’ve also been in increasingly regular communication with NCI regarding the upcoming site visit. Things are on track as we proceed with our rehearsals for the presentations and the associated preparations. If you happen to run into Ellen McLaughlin or any members of her team please thank them for all that they’re doing in their work for the Cancer Center.

I was excited to meet with a representative from Springer, the publisher, on July 6th about an Encyclopedia of Cancer Therapeutic Targets. John Marshall will be the chief editor of the volume, and other editors include me, Anton Wellstein, our old friend Ed Gelmann, and Howard Kaufman at Mount Sinai Medical School. We’re going to be creating a novel and easy to use compendium of cancer-related molecular targets that can be used for quick reference, but with links to deeper annotation. This is an exciting project and I look forward to being involved in it.

On July 8th, a delegation of Lombardi faculty traveled to the Walter Reed Army Medical Center to meet with John Potter and his colleagues to discuss possible collaborations. We identified a number of areas of potential interest and we will be following up on many of these. In case anybody is ever dismayed by what they perceive to be excessive bureaucracy at Georgetown, we arrived at Walter Reed in 2 vehicles and after going through security (where my poor car was strip-searched) we proceeded to the parking spots which had been assigned to us. When we got there, we found that each of them was occupied by cars that were traveling with a general. Apparently generals get priority treatment in the army. So we circled Walter Reed for a half hour and I ended up doing the next logical thing – I parked in a Colonel’s spot. Despite the late start, the Lombardi delegation was intrigued by the remarkable clinical and laboratory resources available through collaboration with Walter Reed. But the next time I go, I’m either getting a taxi or hitching a ride with a general.

Best of all, yesterday morning I had the great pleasure of receiving a $40,000 check along with Aziza Shad and David Nelson from the Hyundai Hope on Wheels event. This is a terrific partnership between all of the Hyundai dealers in the country. At the event, children from the pediatric heme/onc clinic dipped their hands in paint and put their handprints on a new Santa Fe Hyundai, and the handprinted car tours the thirty different pediatric cancer centers that receive funds from Hope on Wheels. The check to Lombardi will go to fund the pediatric survivorship program run by Aziza.

Categories
Events Outreach Research

Addressing disparities in our city

I attended the DC Cancer Consortium Meeting at the Cosmos Club last Wednesday night where representatives from Georgetown, GW, Washington Hospital Center, Howard University, and the American Cancer Society met to discuss how to invest in strategies that will reduce cancer incidence, morbidity, and mortality in the District. For me, one of the highlights was seeing Arnie Potosky in action. I had invited him to discuss a proposal he’s putting together to establish a District of Columbia Cancer Outreach, Research, and Evaluation Database. It’s still under active discussion, but we’re hopeful that it or something like it will be adopted by the consortium. Steve Paterno also presented a very interesting proposal for a patient navigation network for the District. What pleases me about these initiatives is that they provide us with collaborative outlets for addressing disparities and health care access and care for our city.

Thursday morning I met with Lucile Adams-Campbell to get her thoughts about how we might coordinate obesity and cancer initiatives. We cam out with some exciting ways of connecting our science with the outreach and population intervention studies. These were echoed in a later meeting I had with Peter Shields.

After my meeting with Lucile about obesity, I then tried to increase the level of obesity at Lombardi by taking the CCSG team to lunch at the French Embassy. It was great to have a formal opportunity to thank them for a wonderful job and their hard work on getting the grant out the door.

I’m looking forward to attending the Gala Benefit Committee Reception tonight at the home of Darby and Monte Gingery, who are good friends of Tanya Potter Adler and Howard Adler who are this year’s Gala co-chairs. I will be joined by several of my Lombardi colleagues to thank the committee for all its hard work and provide continuing inspiration for our old and new friends who actively support the cancer center. By the way, you may want to check out the new website for the Lombardi Gala, which launches on Friday.

On Thursday, the Shared Resource Directors and Managers attended the first organizational meeting as we gear up to get the posters ready for the site visit. I was very gratified to see a member of nearly every Shared Resource in attendance, and I look forward to reviewing the poster drafts in the coming weeks.

I’m also looking forward to visiting Ohio State on Friday to present Grand Rounds there. I’m particularly interested in the opportunity to present some data from lab, which was just submitted yesterday for publication. It’s nice to know that I can continue to stay active in the laboratory and the clinic. It reminds me why I’m here and why it’s important to have cancer centers.

I won’t be here next week. I’m taking a week off and Harriet and I will be in an undisclosed and unfindable location. So don’t expect any blogs next week.

Categories
Clinic Events

Highlights

I went to Franklin Square Hospital on Tuesday to meet with John Zapas. He is chief of surgical oncology there and also happens to be head of Georgetown University’s oncology IRB. He is interested in melanoma and is academically-oriented, as are his colleagues at Franklin Square. I came away from those meetings with a request from John to include him and his colleagues as Lombardi members. Since Franklin Square is a MedStar hospital there is a natural affinity for interaction and collaboration in the future.

Speaking of MedStar, I was delighted to congratulate Rich Goldberg on his promotion to interim President of GUH. Also congratulations to Joy Drass in her new role as Executive Vice President for Operations of MedStar South. Her tenure as President here was remarkably successful in that she rescued the hospital from ruin and positioned it for future growth and success.

One of the highlights of my week was going to Politics and Prose Tuesday night to hear PJ O’Rourke speak about his new book, “Driving Like Crazy”. I’ve enjoyed his writing for years and he’s nearly as funny and insightful in person.

Another highlight was the Men’s Event on Monday Night. We had almost 160 people turn out to support our research programs in prostate cancer. I was touched by everyone’s commitment and generosity to our mission. It was especially nice to meet Charlie Neal who is an ESPN sportscaster with the most amazing bass baritone speaking voice I’ve ever heard. It was also great to see long-time Lombardi supporters Paul Schweitzer, Jack Schneider, Harvey Weiss, and many others, including Howard Adler. Howard and his wife Tanya Potter Adler are the chairs for this year’s Gala.

For once I wasn’t the tallest guy in the room because one of the guests was former Congressman Tom McMillen who played basketball at Maryland and then in the NBA for twelve years. This was his first Men’s Event, and like many others, I’m sure he was moved by our mission.

That’s all for now.

Categories
CCSG Events Outreach

Getting the Word Out about Lombardi

I had a wonderful wet weekend cheering on the Lombardi team at the Avon Walk. I was proud of our team this year. We had 23 walkers who combined to raise $46,000.  It’s nice to be able to have a bigger impact for such a wonderful cause. Even more importantly the Lombardi cheering section was loud and quite prominent at many of the cheering stations. This was a big change from last year where only one person served as the Lombardi-designated cheerer.

You can bet that many people noticed our presence this year, and many people commented on Lombardi’s walking team, cheerers, and coordination of medical services for the Walk. We received a lovely check from the Avon Foundation at the Walk’s closing ceremony which will support the operation of the Capital Breast Care Center, and the head of the Foundation made special note of Lombardi’s increased presence at the Walk. As I’ve told you before, I want Lombardi to be a presence at important events like this, and this was a good start. But wait till next year!

On a related note, I had the horrifying experience of waking up to the sound of my own voice on the radio on Monday morning. Beth Beck and I were interviewed by local NPR affiliate WAMU about the Avon Walk, and when my alarm went off at 6 AM the next day, this is what I heard.

I attended the NCI Cancer Centers director’s retreat in Pentagon City on Monday evening and Tuesday (where John Niederhuber congratulated me on the successful Avon Walk – he must have heard the WAMU story). It appears as if the cancer centers should not expect a windfall for essential infrastructure from the stimulus package or the growing NIH budget. However it is clear that pay lines will be supported for R01s, with 16% pay lines and the flexibility to reach up to the 25th percentile in some instances. So let’s keep writing those grants.

Yesterday, I spent my day with the Lombardi Celebration Committee describing the work we do. I was inspired by the dedication and added energy of the group coming from new members. This is an important way to get the word out about Lombardi, and I look forward to attending the Celebration on November 7th.

I then drove directly to Capitol Hill to participate in a effort on behalf of cancer centers organized by the AACI and Friends of Cancer Research. I had a chance to meet with Legislative Assistants of several Members of Congress. While one never knows if those activities yield immediate dividends, it was nice that one of the Legislative Asssistants said, “It’s nice to see you again,” which means our message is getting across.

Oh, by the way, we have a core grant due on the 25th. We’re now in the home stretch and the final pieces of the puzzle are falling into place. If you happen to run into Ellen McLaughlin or Stephanie Pomerleau in the hallway, please give them your thanks because they are doing a wonderful job managing the complex task of putting together the grant submission.

Categories
CCSG Education Events

The importance of teaching (and the core grant)

Congratulations to Aykut Üren for receiving the Geza M. Illes Award for Excellence in Teaching at the Georgetown University School of Medicine’s 31st Annual Golden Apple Awards Ceremony. The award honors an outstanding first-year teacher “who serves as an inspirational role model in the field of gross anatomy.” This is a real testimony to his dedication and effectiveness as a teacher. It’s wonderful to know that a fine researcher such as Aykut is able to find the time and energy to make a contribution to training medical students. Speaking of Aykut’s research, he is hosting the Wnt 2009 Conference to be held on June 11-14 here at Georgetown’s Gaston Hall.  Clearly he is able to do more than one thing well at a time!

I’ve been feeling a bit jet-lagged. I was in Whistler, British Columbia, co-chairing a Keystone Symposium on Antibodies as Drugs. The meeting was co-located with the Targeted Cancer Therapies Keystone Meeting so I had the wonderful opportunity to go to two meetings in areas of great interest to me. I am told that the skiing was great though all I remember of my down time was staring into a laptop screen editing core grant program write-ups. At least I didn’t break an ankle while using track changes.

Last Thursday afternoon, I chaired the Systems Medicine task force for the GUMC strategic planning initiative. We’re making good progress in understanding how to roll out systems medicine at Georgetown University Medical Center using G-DOC as a template. However we still have a lot of work to do.

I also chatted with Joe Teague and Elena Jeannotte about the upcoming Lombardi Celebration on November 7th. I am pleased to announce Tanya Potter Adler and her husband, Howard Adler, will be our co-chairs. Tanya is the daughter of Dr. John Potter, the founding director of Lombardi, and she is embracing her role with enthusiasm. We are grateful to her for taking on this responsibility.

On the media front, kudos to Todd Waldman for his remarkable appearance on CNN. In contrast to my interview on Fox 5 last Wednesday (only one sentence was picked up), Todd really had a chance to share his ideas, and to an international audience.

Finally, I plan to spend the weekend (when I’m not reviewing core grant write-ups) preparing responses to the various ARRA initiatives. I hope everyone is taking advantage of this remarkable funding mechanism. It is a great way to add depth and strength to our respective research programs.If you want to know more about the opportunities, please refer to the following links:

Categories
CCSG Events

Funding feast and famine

I’ve had a very busy week, but I believe I will be a lot busier between now and the end of May. Besides the massive amount of work required to get the core grant finalized – and I should note that I am not bearing this burden alone – we are currently being subjected to the perfect storm of funding opportunities from the stimulus package. Everyday it seems that another funding opportunity is released and I am impressed by the vigorous response that many of us at the cancer center are showing to the opportunities being presented. I must say it feels peculiar to have such a potential feast provided to us in the midst of an economic famine at the national and international levels. All I can be sure of is that I will be replacing my blackberry hunch with laptop postural fatigue over the next few months.

Peter Shields, Joe Teague, and I attended a cocktail party hosted by Senator Mary Landrieu (D-LA) to support the Capital Breast Care Center. The event was at the Senator’s lovely home in the Capitol Hill neighborhood. The attendees responded warmly to our remarks, though I was surprised that so few of them knew about the CBCC, or knew where it was, even though it’s in their neighborhood. This treasure has been buried, but we will do what we can to assure that everyone knows that it is a special resource to the residents of the District.

Please mark your calendars for the reintroduction of the Lombardi Celebration, formerly known as the Lombardi Gala, on November 7th. We have identified and look forward to announcing the names of this year’s co-chairs.

I spent the first two days of this week in New York City chairing a grants review panel for the Israel Cancer Research Fund. Israeli scientists provide us with clear evidence that it is possible to do wonderful science in a resource constrained environment that would make those of us at Lombardi feel as if we were working in opulent splendor.

Categories
Events Research

Stimulating discussions – and the stimulus package

It was a great pleasure for me to see Stan Gerson when he came to Lombardi to deliver Grand Rounds last Friday. Not only is he an old friend and study section colleague, but he’s also a valued member of our External Scientific Advisory Committee (ESAC). As a cancer center director, his perspective and insight is very valuable to me as we head into the CCSG renewal. Even though Stan usually slept during sections on tumor immunology, I forgive him his transgressions and found his presentation on Friday to be interesting and provocative. I was, however, disappointed to be one of only a handful of clinicians in the audience. I don’t see how we could have better speakers at Grand Rounds, so hopefully this will change. Everyone is busy, but the opportunity to participate in exciting academic activities is and will remain a core value of this cancer center.

Harriet and I attended the Pediatrics Gala at the Omni Shoreham Saturday night. It reminded me that Jeff Toretsky and Aziza Shad are hosting a very significant symposium on Targeted Therapy for Childhood Cancers that will feature a great lineup of speakers. It will be held on Friday, April 17 in the Research Building Auditorium. Please remember to put it on your calendar and register for the event.

On Monday we had our first full senior operational team meeting where we welcomed John Marshall into the group. The senior operational leadership team now consists of Peter Shields, Michael Vander Hoek, John Marshall, and myself. I think it’s important to include a strong clinical perspective in these weekly operations meetings, and John’s input proved invaluable to the discussions.

I have also had several meetings related to fund raising in the past week. Aside from my routinely scheduled meeting with Joe Teague, I also met with the University Office of Advancement’s “Discovery Intiative” team, which consists of roughly 20 individuals who interface with Georgetown alumni, friends, and supporters. I was able to share our vision for the future and can assure you that vision was enthusiastically received. Since these people engage their constituents looking for opportunities to create relationships that can benefit the cancer center, I came away quite encouraged.

Finally, you have no doubt been bombarded by a variety of messages regarding stimulus package grant opportunities. We are doing our best to coordinate our activities and provide support to facilitate successful applications. The large construction grants will be handled centrally through the University, but many of the other proposals, including grant supplements, should be considered by all of us. If you have not already done so, please let us know your plans for submitting grants using this form.

Have a great week.

Categories
Events Research

I spoke too soon

So it was 13 degrees outside when I left for work yesterday morning. It’s so much fun to live in “semi-tropical” Washington.

Despite the climate, I did have a scientifically interesting week. As I mentioned in my last post, Khaled El-Shami, Carolyn Hurley, and I met last Thursday with investigators from the NCI bone marrow transplant (BMT) program to discuss a really exciting protocol involving the infusion of allogeneic natural killer cells in patients with refractory myeloid malignancies. Key to the protocol will be the prospective haplotyping of natural killer cells by Carolyn; this will help select patients with appropriate mismatches that can drive natural killer cell recognition and attack against myeloid leukemia cells. The protocol is undergoing refinement as a result of our discussions and I’m hopeful to get it started in the very near future.

On Tuesday afternoon I had the pleasure of participating in the annual Spring Convocation in Gaston Hall, and was proud to have the opportunity to congratulate Bob Clarke and Mary Beth Martin for receiving vicentennial medals for 20 years of service to Georgetown. Joseph Neale, professor of biology, gave a thoroughly entertaining review of his life at Georgetown. Following the Convocation, the 1789 Society dinner was held in Riggs Library, celebrating the University’s most generous supporters. It’s reassuring to know that even during these difficult economic times that our core philanthropic support remains strong.

Last night, Harriet and I attended the Friends of Cancer Research annual awards banquet at the Hotel Monaco. It was great to see Ryan Hohman, who now works for Friends of Cancer Research, and we spent the evening with Peter Shields and his wife Leslie. Ellen Sigel, who heads Friends of Cancer Research, is a genuine force in the cancer advocacy world and has focused effectively on legislative remedies including advocacy of the Kennedy-Hutchison bill. Our location in DC and our identity as part of Georgetown University give us many opportunities to be a part of the action and to hopefully play a role in defining our nation’s agenda with respect to cancer research.

Finally, if anyone missed the Town Hall meeting yesterday, I have posted the slides online. I also recommend that everyone peruse the slides from Howard Federoff’s meeting about the stimulus bill.